The Biomedical Science group is a multi-disciplinary team with research interests in a number of areas including gene regulation, drug development, diagnostics and oxidative stress is in the areas of diabetes, cardiovascular disease, infection control and mental health. The following are key areas of research carried out by the group:
- Antioxidants and biomarkers of oxidative stress
- Antioxidant and nutraceutical efficacy
- Therapeutic and non-therapeutic antimicrobial activities
- Novel antimicrobial flavonoids
- Hypoxia/hyperglycaemia and endothelial function
- Glucose regulation of gene expression
- Atherosclerotic plaque development and plaque rupture
- Cannabinoids in cardiovascular pathophysiology
- The role of PPAR delta in inflammation and macrophage activation
- Macrophage integrin- and PPAR delta signalling pathways
- Hypoxia and contraction in the pulmonary vasculature
- Tumour selective cytochrome P450 enzymes as novel cancer therapies
- Tumour selective markers
- Collagen in cardiovascular pathologies
Applications are encouraged from science graduates who would like to work in any of the above research topics. Enquiries should be e-mailed to firstname.lastname@example.org.
Recent refurbishment of the research facilities has resulted in a range of exceptionally high quality laboratories that incorporate cell culture (primary cultures and cell lines) and microbiological suites, molecular biology (PCR, RT-PCR, comet assay), biochemistry (Western and Northern blotting, GC-MS, LC-MS, HPLC and capillary zone electrophoresis), physiology and pharmacology (electrophysiology, myography, in vitro and in vivo assessment of cardiac and vascular function; platelet and leukocyte function) and tissue structure (histology, immunohistochemistry, fluorescence microscopy).
The Biomedical Sciences group currently has about 7 PhD students and 2 Post-Doctoral Research Fellows, with funding from the British Heart Foundation, Tenovus, the Coronary thrombosis Trust and other sources.